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Articles

CJPLS: VOL. 12, NO. 2, DECEMBER 2024 (Ongoing)

Tissue antioxidant enzyme activities and lipid profile of experimental rats fed with Waltheria indica leaf diets

Submitted
May 31, 2024
Published
2024-11-05

Abstract

Hypercholesterolemia is a specific genetic condition characterized by excessively increased plasma cholesterol concentrations. Although treatments through statins have recorded exponential success over time, regrettably, several patients have yet to attain the minimum levels of low-density lipoprotein-cholesterol (LDL-Ch), evidenced by the high cardiovascular outcomes after treatment. Hence, this research aimed at evaluating the effect of Waltheria indica leaf diets on the lipid profiles and antioxidant activities in male albino rats weighing 40-45 g, which were grouped into three: Group A (basal group without cholesterol), Group B control (diet + 1% cholesterol) and Group C test diet (1% cholesterol + 10% Waltheria indica leaf sample) and fed for 21 days and weighed before sacrifice. After the last day of feeding, the Serum and liver were excised, and lipid profile and antioxidant enzyme activities were analyzed using standard methods. Serum total cholesterol (mg/dl) decreased significantly (p<0.05) from 83.88 ± 2.74 in control rats (group B) to 23.14 ± 1.05 in group C rats. Also, serum high-density lipoprotein (mg/dl) increased significantly (p<0.05) from 17.09 ± 0.71 in control rats to 33.25 ± 4.01 in group C rats. The serum malondialdehyde level decreased markedly from 8.68 ± 0.07 in group B rats to 5.74 ± 0.40 in group C rats. The activity of Serum Catalase significantly increased from 2.29 ± 0.15 in group B rats to 3.75 ± 0.13 in group C rats. This study demonstrates the lipid-lowering potential of Waltheria indica leaf diets and its protective effects against oxidative stress, which holds promise in managing and treating hypercholesterolemia.

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