Effect of different high-fat diets on lipid profile in albino rats

Chukwuemeka Pius Nwokoro, Ajuwon Olawale — Thu, 23 Jan 2025 00:00:00 +0000

Abstract:

High-fat diets and sedentary lifestyles are the main causes of obesity, which is a major risk factor for chronic illnesses like heart disease, high blood pressure, type 2 diabetes, chronic kidney disease, and several types of cancer. This comparative study examines how male albino rats' lipid profiles are affected by high-fat diets made from widely eaten vegetable oils. A total of 48 male albino rats weighing between 100 and 150 grams were randomly assigned to five groups of eight. As the control group, Group 1 was given a diet that contained 11% energy from 5% soybean oil. Rats in Group 2 were given a diet that contained 30% crude palm oil and 2.5% soybean oil (CPO group). Rats in Group 3 were given a diet that contained 30% refined palm oil and 2.5% soybean oil (RPO group). Rats in groups 2–5 were fed a diet consisting of 2.5% soybean oil and 30% groundnut oil (GO group) and Group 5 rats were fed a diet consisting of 2.5% soybean oil and 30% shea butter (SHB group). Blood samples were taken at the end of the 8-week feeding protocol in order to evaluate lipid profiles, and the atherogenic index and coronary risk index were also computed. The results indicated that there were no significant differences (p < 0.05) in the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, or high-density lipoprotein cholesterol between the rats fed high-fat diets and the control group. In conclusion, the high-fat meals assessed in this study did not negatively impact the rats' lipid profiles and fared similarly to soybean oil.

Covenant Journal of Physical and Life Sciences

Effect of different high-fat diets on lipid profile in albino rats