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Vol. 4 No. 2: December, 2016

Preparation, Release Pattern and Antibacterial Activities of Chitosan-Silver Nanocomposite Films

  • Sonde O. I.
  • Ogungbesan S.O.
  • Olaniyan J.O.
  • Oloyede A.R.
  • Idowu M. A.
  • Afolabi T.A.
  • Adetunji O.
  • Dare E. O.
January 26, 2017


<p>The present study examined the preparation of chitosan-silver   nanocomposite films as carriers for silver release pattern. Chitosan a biopolymer   having immense structural possibilities for chemical and mechanical modifications   to generate novel properties, functions and applications. Chitosan–silver   nanocomposite films has been synthesised by reduction method, which is a simple   and inexpensive method. The chitosan-silver nanocomposite films was   characterized in terms of its surface plasmon resonance and crystalline structure by   using UV-Visible spectroscopy, X-ray diffraction, Fourier transform infrared and   Scanning electron microscope. Swelling and release studies were carried out on   crosslinked and un-crosslinked nanocomposite films. Antibacterial activities of   chitosan-silver nanocomposite films were investigated on some pathogens:   Staphylococcus aureus, Shigella dysenteriae, Escherichia coli, Salmonella typhii   and Klebsiella pneumonia using agar well diffusion method. crosslinked chitosan-silver nanocomposite demonstrated a slower release pattern relative to un-crosslinked chitosan-silver nanocomposite. The crosslinked and un-crosslinked   nanocomposite became dislodged and completely released at 120 minutes and 90   minutes respectively. The results of the antibacterial activities revealed that the   cross-linked chitosan-silver nanocomposite films has higher antibacterial   properties than un-crosslinked chitosan-silver nanocomposite films. This study   provides nanocomposite films potentially useful for delivery system.</p>