This study explored the impact of gender on knowledge management practices and employee engagement in selected commercial banks in Akoka, Shomolu LGA, Lagos State, Nigeria. A descriptive research design was adopted, and data were collected from 200 conveniently sampled employees across ten commercial banks using a structured questionnaire. The instrument incorporated the Knowledge Management Assessment Instrument (KMAI) by Lawson (2003) and the Utrecht Work Engagement Scale (UWES) by Schaufeli et al. (2006), both with established reliability. Data were analyzed using SPSS version 22, employing descriptive statistics and Independent Samples t-tests to assess gender-based differences. Results revealed no significant gender differences in most aspects of KM, except for the storing knowledge dimension, where male employees scored significantly higher. In contrast, all three dimensions of employee engagement (vigour, dedication, and absorption) showed statistically significant gender differences, with male employees reporting higher engagement levels than their female counterparts. These findings highlight the need for gender-sensitive strategies to boost female engagement while maintaining inclusive knowledge-sharing practices across the sector.