In today's increasingly interconnected and fast-paced world, innovation and technological entrepreneurship have emerged as key drivers of economic growth, fostering job creation, competitiveness, and sustainable development. Nigeria, Africa's largest economy, is poised to leverage these crucial elements to propel its own economic transformation. Technological entrepreneurship has become a critical catalyst for economic growth worldwide. This paper explores the potential of technological entrepreneurship as a key driver to propel Nigeria's economy forward, generate employment opportunities, and foster innovation. The paper highlights the current landscape of technological entrepreneurship in Nigeria and identifies the challenges and barriers hindering techno-entrepreneurship growth in Nigeria. It further describes the various government initiatives as well as key issues, difficulties, and opportunities for growth of technological entrepreneurship in Nigeria. It draws on some global best practices and case studies on technological entrepreneurship to provide valuable insights into successful strategies and approaches that can guide the case of Nigeria. The paper closes with achievable recommendations to policymakers, entrepreneurs and stakeholders’ to harness Nigeria’s technological potential and position it as a prominent player in the global innovation ecosystem.