Entrepreneurship and skills development centers have been established in Nigerian universities to actively support the development of entrepreneurial mindsets that would encourage students to create jobs after graduation. However, the batched approach to the provision of entrepreneurial support to students appears to be reducing the extent to which desired outcomes are achieved. This study investigates the relationships between student support services, entrepreneurship skills development, and student entrepreneurship in public and private universities in Lagos and Ogun States. A mixed-method research design was employed. The sample for this study comprised of 2394 students and 6 directors of entrepreneurship centers selected through a multi-stage sampling technique. Two objectives, two research questions, and one hypothesis were formulated to guide the study. Data were analysed through frequency counts, mean, and standard deviation, while the hypothesis was tested using Pearson Product Moment Correlation. Qualitative data were analyzed through verbatim reports and emerging themes and patterns from transcribed key informant interviews. Results showed a strong positive relationship (r = 0.42*, P =.01<0.05) between student support and entrepreneurship skills development thereby providing evidence of student support being a significant driver of entrepreneurship development. It was concluded that student support programs promote student entrepreneurship in Higher Educational settings but such support needs to be personalized to meet the diverse needs of student entrepreneurs. Among others, it was recommended that universities should invest in partnerships that will drive informal and personalized support in terms of internships, competition, and seed grants that comprised the use of mentors as hand-holders. Such support should however be structured in ways that make measurement of impact possible.