One of the major challenges facing Akwa-Ibom State is poverty. This is due to the high rate of unemployment especially among the youths. With over 52 percent of the youth in the State unemployed and poor, entrepreneurship becomes an alternative means to not only traditional economic development strategies and policies but also as the best strategy for eradicating poverty. This paper aims at examining the importance and challenges of entrepreneurship in poverty eradication as well as strategies for promoting entrepreneurship among Akwa Ibomites. Data was gathered from secondary sources such as relevant books and internet materials. Findings indicated that entrepreneurship have significant effects on poverty eradication. The paper concluded that poverty goes beyond lack of resources. It extends to malnutrition, poor sanitation, lack of access to safe drinking water, education, health care, social inequality, insecurity, total lack of opportunity for personal growth and self-realization. These problems can only be remedied through the development of entrepreneurship skill among the citizens. The study recommended among others that entrepreneurship development should be inculcated into the school's curriculum to promote human empowerment and development through entrepreneurial education and training