Emotional exhaustion occurs when there is intense demand in workplace. The rate at which Ministers of God exhibit emotional exhaustion has been on the increased over the years. This study investigates the influence of personality traits, church-related stress, gender and age on emotional exhaustion among Ministers of God in Lagos, Nigeria. The study adopted ex-post facto research design using three instruments: Big Five Personality Scale, Church-related Stress Scale, and Emotional Exhaustion Scale to conveniently sample 202 (Males 167, Female 35) Ministers of God. Three hypotheses were tested using standard multiple regressions and t-test of independent sample mean at level of significance. The result revealed that personality traits (extraversion, agreeableness, openness, neuroticism and conscientiousness) and church-related stress jointly predicted emotional exhaustion among Ministers of God in Lagos. Also, agreeableness, neuroticism and church-related
stress independently predict emotional exhaustion among Ministers of God. However, gender and age did not influence emotional exhaustion among Ministers of God. The study concludes that personality traits and church-related stress are excellent predictors of emotional exhaustion among Ministers of God in the study population. It is recommended that Ministers of God should develop effective coping and problem solving techniques so as to manage both marital affairs and church activities to reduce emotional exhaustion.