This study investigated the relationship between religiosity/spirituality and emotional homeostatic disequilibrium (EHD) among married civil servants in Bayelsa State, Nigeria. One research question and one null hypothesis guided the investigation. The expost facto correlation design was adopted for the study and the population consisted of all married civil servants in the mainstream civil service of Bayelsa State, about 8,449 as at the time of this study. A sample of 780 (10.9%) were selected through purposive sampling procedure. Data collected from 766 subjects with two instruments: The Emotional Homeostatic Disequilibrium Scale (EHDS) and Religiosity/Spirituality Scale (RSS) were analyzed with correlation and regression statistics using SPSS version 23. It was discovered that religiosity/spirituality was significantly related to EHD among married civil servants in Bayelsa State, Nigeria. Following this finding, it was recommended that counselors, psychologists and psychiatrists should consider the religiosity/spirituality factor when married clients present EHD cases for psychotherapeutic intervention in order to achieve optimal results.