This article examines the indigenous psychotherapy model Meseron Therapy and chronicles some of its applications. The Meseron Therapy was developed by Professor Alfred Awaritefe in 1995. Meseron means “I refuse” in the Urhobo language. The therapy focuses on the power of the spoken word and how it is able to effectively change a person and a person’s condition by encouraging the person to think, say, and do things that will cause a change in the person’s condition. The origin of Meseron therapy was discussed, Meseron as a motivational theory and cognitive therapy was examined. The Practice of Meseron Therapy, the basic assumptions, aims and goals, therapeutic implications, and the techniques and tools of Meseron therapy were highlighted, with the therapeutic implications of Meseron Therapy further discussed. The article concluded with a call for clinical and counselling psychologists to integrate indigenous psychotherapy methods into their practice. Research endeavors and publications in indigenous psychotherapy methods were also encouraged.