Architecture has always been meant to solve problems by satisfying the enduser emotionally, psychologically or physiologically. This is why architecture is seen as a product of a way of thinking and creativity which requires manipulation of space and nature as source of inspiration and tools to relate with in order to solve problems. This paper examines architecture as a product of creativity through the manipulation of space and nature. It further explains the importance of space and natural elements as source of inspiration and interaction for architecture. Methodology of study is qualitative approach using the data collection techniques of archival documents, observation, and typological analysis of buildings / works of some renowned architects as well as content analysis of selected literatures on the subject matter. Findings reveals that architecture built on effective manipulated space and nature inspired structures affect the total wellbeing of humans, people‟s perception of the built environment and the beauty to behold and iconic. The study also reveals that creativity is an important asset in the practice of architecture.