The study examines the effect of entrepreneurial orientation (EO) on micro, small and medium enterprises (MSMEs) performnce in Abia State, Nigeria. Using survey research design, through the administration of structured questionnaire to the chief executives of some selected MSMEs in Abia State, Nigeria. The findings revealed that innovativeness, risk-taking, proactiveness, autonomy, achievement and learning orientations are the critical dimensions of EO driving MSMEs performance in Abia State, Nigeria. While competitive aggressiveness does not significantly affect MSMEs performance. The adjusted R2 revealed that EO dimensions account for 61% variation in MSMEs performance in Abia State, Nigeria. It can therefore be concluded that EO positively and significantly affects MSMEs performance in Abia State, Nigeria. The study contributes to the literature on EO, by examining EO from seven dimensions (innovative, risk-taking, proactive, autonomy, achievement, competitive aggressiveness and learning orientations).MSMEs should develop their innovative, risk-taking, proactive, autonomy, achievement and learning orientations toward attaining increased revenue.