This paper investigates the effectiveness of entrepreneurial education in repositioning the Nigerian youths for sustainable economic development. The major objective of the study is to investigate the roles of key entrepreneurship development education variables such as knowledge-based economy and enterprising culture on economic development variables such as creativity and problem-solving skills that focuses on repositioning Nigerian youths for sustainable economic stability. The research adopts the review of secondary data. The findings shows that entrepreneurship development education that targets the youths is a powerful tool for empowering the economic strength of a nation and as such, it is recommended that University education curriculum should focus more on educating Nigerian youths on the benefits of becoming acclaimed entrepreneurs.