This study examined the relevance of Corporate Affairs Commission to Small and Medium Enterprises (SMEs) in Nigeria with a case study of KONUM FARMS Limited, Amai, Delta State. The research problem is borne out of the general outcry that government establishments do not perform efficiently and effectively because they are not profit oriented organizations. The objectives of the study were, among others, to appraise the functions and roles of Corporate Affairs Commission as a regulatory body under the Nigeria Law. The research questions and hypotheses were structured in line with the objectives of the study. The research methodology explained the techniques adopted in carrying out the study. The descriptive research design was used. The population of the study comprised the Management and Staff of Konum Farms Limited, Amai. The sample size was determined using the simple percentage statistical tool. A questionnaire instrument was used for data collection. The data were presented in tables and analyzed in percentages. The chi-square was used to test the hypotheses. The findings were, among others: (i) that frequent changes and sometimes conflicting government monetary policies had in many ways tended to hurt SMEs in Nigeria. (ii) that government neglected SMEs in the area of incentives and infrastructural development to facilitate business entity. (iii) that government does not give SMEs in Nigeria financial support in order to thrive. It was recommended, among others, (i) that government should stop improper implementation of its policies towards SMEs. (ii) that government should enhance its incentive measures and infrastructural development to SMEs. (iii) that government should adequately support the SMEs through lending institutions to enhance their capacity base.