This study examined gender perspective of Nigerian newspapers coverage of COVID-19 responses and politics associated to the responses. Agenda setting and feminist theories were used as theoretical framework. The study adopted the content analysis method. Newspaper editions that carried headline stories of COVID-19 responses and political activities were purposefully selected from 366 editions of The Punch, Vanguard, and Daily Trust newspapers published in April, May, June, and July, 2020, when COVID-19 response was high. This study then examined the 946 lead reports on the COVID-19 responses and the 302 lead reports on the political activities that appeared in newspapers, from a gender perspective. The findings reveal that lead stories on COVID-19 responses were the greatest, while politics was the fifth within the study time frame. This shows that the newspapers attached importance to COVID-19 lead stories. The decrease in the frequency of newspaper stories on COVID-19 responses following the confirmation of the index case in February was normal, as the media would ordinarily set an agenda on a quite current. Also, just 103 (11.0 percent) of the COVID-19 response lead stories were sourced from women, while 379 (34%) were obtained from males: 76 (25.0 percent) of the political lead reports were derived from women, as against 208 derived from men. It is recommended that the media continue to pay attention to serious issues in the society and particularly pay special attention to such pertinent issues from a gender-balanced frame.