The aim of this study was to assess the knowledge and uptake of the tetanus toxoid vaccine among pregnant women in General Hospital, Nguru town. A stratified random sampling technique was adopted to cover 152 pregnant women of different categories. A well-structured questionnaire was used to collect data and the test-retest method was used to check the questionnaire's consistency. The obtained data were statistically analysed and the formulated hypothesis was tested using Chi-square. The results show that Hausa/Fulani (50.7%) and the age bracket 21-25 years (46%) constituted the majority. Also, about 97% of the respondents have an awareness of TT and 76.32 % knew that the TT vaccine is for prevention. Though 91.45% of the respondents have ever received the vaccine in their lifetime, only 13.8% could ascertain when to receive it. About 57% were willing to receive the complete 5 doses, 71.2% were willing to receive at least 2 doses during pregnancy and 52.6% are willing to continue the TT regimen after delivery.
Also, the study shows a significant association (P value = 0.022) exists between respondents’ awareness and TT vaccine uptake; hence the null hypothesis is rejected. However, there is no significant association between the level of knowledge and TT vaccine update (p = 0.99). It can be concluded that many respondents have awareness and are willing to take TT vaccine. However, knowledge of when to take the vaccine is inadequate. Hence, to increase TT vaccine uptake level in the area more awareness is recommended.