The increasing demand for fine aggregates in turn has led to the astronomical increase in the cost of procuring construction materials thereby making it difficult to meet the shelter provision requirement of the teeming population of a country such as Nigeria. This study aims at optimizing and developing predictive models on the strengths and durability of reinforced laterized concrete using response surface methods with laterite being used as a partial replacement of fine aggregate in reinforced concrete. In this study, the optimized laterite content was determined at replacement level of laterite to fine aggregates at 0, 10, 20, 30 and 40% with a mix ratio of 1:2:4 and a water cement ratio of 0.65, while for the water absorption, the percentages replacement of laterite to fine aggregates was 0, 10 and 20%. The results of the strength and the durability obtained from the laboratory were subjected to statistical analysis using design expert software version 13(2021). The strength and the durability were found to be 19.044 N/mm2, 27.304 N/mm2 and 3.809% for the compressive strength, flexural strength and water
absorption at 10% laterite content at 28 days curing age. It was concluded that, to achieve the maximum strength (compressive and flexural) and durability requirements of laterized concrete should be produced by replacing fine aggregate with 10% laterite and cured at 28 days. The developed models could be used for the predictions of desired strengths and durability of the reinforced laterized concrete.