Improvement of Oral Glucose Tolerance and Total Lipid Profile of Diabetic Rats Treated with Ficus exasperata Leaf-Based Diet

Soji-Omoniwa Omolola & Oloyede Hussein Oyelola Bukoye

Abstract


The aim of this study was to investigate the effect of Ficus exasperata leaf-based diet (FELD) on oral glucose tolerance and total lipid profile of type 2 diabetic rats. Forty-eight wistar rats were randomly selected into 8 groups of 6 animals each. All experimental animals apart from the positive control group were administered with 10 % fructose solution ad libitum for 2 weeks, while those in the negative control group received distilled water. The remaining groups were diabetic rats treated with 10, 20, 30, 40 and 50 % FELD for 16 days. Oral glucose tolerance test (OGTT), cholesterol, triglycerides, high and low density lipoproteins (HDL and LDL) were assayed for. Result of OGTT before commencement of treatment showed significant increase (p < 0.05) in the blood glucose concentration after 30 mins of oral glucose load which was not restored back to the basal level after 2 hours. OGTT result by the 13th day of treatment showed significant decrease (p < 0.05) in glucose concentration of FELD-treated diabetic rats 2 hours after glucose load. There was a significant decrease (p < 0.05) in the concentration of cholesterol, triglycerides, LDL and a significant increase (p < 0.05) in HDL concentration of FELD-treated diabetic rats. In conclusion, incorporation of 30, 40 and 50 % F. exasperata leaf into diet and consumed for 16 days improved glucose tolerance and total lipid profile of diabetic rats.


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