The study examined information literacy skills as determinants of social media use among private secondary school students at Akinyele Local Government, Ibadan, Nigeria. Survey design of the correlation type was used for the study in which questionnaire was the instrument employed to collect data from 210 Senior Secondary School 3 science students from the selected private secondary schools using multi-stage random sampling technique. Statistical Package for Social Sciences Software (SPSS) version 14 was used to analyse collected data while table, percentage and mean distributions were used for the presentation of findings. The findings revealed that most of the respondents were aware of Google+, Twitter, Facebook, YouTube, and Flicker to: upload and view pictures and photographs (mean = 3.10), for chatting (mean = 3.05), get information on politics and national development matters (mean = 3.04) and commenting on friends’ profile. Findings thus revealed that the respondents had a very high level of information literacy skills. The peculiar challenges faced by the respondents on use of social media were: shift of attention and disengagement from school educational activities, and cyber-bullying. Consequent on the result of findings, some recommendations were highlighted for private secondary schools in Akinyele Local Government, Ibadan, Nigeria.